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Pfizer And University College London Announce Collaboration To Advance Development Of Stem Cell-Based Therapies

Goal of Collaboration Between Pfizer Regenerative Medicine and UCL is the Development of Treatment for Macular Degeneration

Thursday, April 23, 2009 - 5:30pm
EDT

(BUSINESS WIRE)--Pfizer Regenerative Medicine today announced that it has entered into a collaboration and license agreement with University College London focused on gaining better understanding into how to develop stem cell-based therapies for certain ophthalmic conditions.

The Pfizer/UCL collaboration brings together the pioneering work of university researchers in the field of cell-based therapies and Pfizer’s expertise in the design and delivery of therapeutics. Pfizer’s contributions will include expertise in the design and execution of clinical studies and interaction with global regulators as well as in product manufacturing techniques. The collaboration will examine how human embryonic stem (hES) cells differentiate into retinal pigment epithelium (RPE) with the goal of developing stem cell-based therapies primarily for wet and dry macular degeneration (AMD).

“We are excited to be working with pioneers in the field of stem cell ophthalmology from UCL,” said Ruth McKernan, PhD, Chief Scientific Officer of Pfizer Regenerative Medicine. “While we have much to learn about how stem cells can be used therapeutically, we are confident that this relationship will increase that understanding and help us advance to a time when our work may benefit patients worldwide.”

Under the terms of the agreement, Pfizer will provide funding to UCL to enable research into the development of stem cell-based therapies for AMD as well as other retinal diseases. Pfizer is granted exclusive worldwide rights to develop and commercialize an RPE stem cell-based therapeutic in the ophthalmology field. After the completion of preclinical safety studies, Pfizer will have the option to conduct clinical trials to determine efficacy of treatment and commercialize any resulting product.

Pfizer is a leader in the development and marketing of medical therapies for ophthalmologic disease and has active efforts in retinal diseases, glaucoma and dry eye syndrome. The alliance with UCL will help Pfizer to remain at the leading edge of research into new therapies for ophthalmic disease.

“We have not only the benefit of Pfizer’s experience of the regulatory process and their expertise in stem cell technology but the ability, if this works, to produce on a much larger scale. It has huge implications, not only for our project, but for the field of regenerative medicine as a whole. And it is great that Britain is at the forefront of this research,” said Professor Pete Coffey, UCL Institute for Ophthalmology and Director of the London Project.

In November 2008, Pfizer launched the Pfizer Regenerative Medicine research unit. This independent research organization will build on Pfizer's years of experience in this field and recent scientific progress in understanding the biology of stem cells and the opportunity it provides to discover and develop a new generation of medicines for major medical needs. Initial research in this area by Pfizer was focused on the development in drug discovery tools and now expands into developing a new generation of regenerative medicines for major medical needs that could benefit millions of patients worldwide.

The agreement with UCL adds to a range of collaborations and licenses with public and private institutes involving experts in this emerging area of biomedical research, of which Pfizer is at the forefront. These collaborations support the evaluation of alternative cell sources, explore the control of stem cells with small molecules and seek to optimize the production of certain cell types for potential use as therapies.

These collaborations place Pfizer at the cutting edge of efforts in the field of regenerative medicines and support the company’s goal to be a leader in the discovery and development of biotherapeutics and in bringing life-changing medicines to patients in need.

Pfizer Inc: Working together for a healthier world™

Founded in 1849, Pfizer is the world's premier biopharmaceutical company taking new approaches to better health. We discover, develop, manufacture and deliver quality, safe and effective prescription medicines to treat and help prevent disease for both people and animals. We also partner with healthcare providers, governments and local communities around the world to expand access to our medicines and to provide better quality health care and health system support. At Pfizer, more than 80,000 colleagues in more than 90 countries work every day to help people stay happier and healthier longer and to reduce the human and economic burden of disease worldwide.

About UCL

Founded in 1826, UCL was the first English university established after Oxford and Cambridge, the first to admit students regardless of race, class, religion or gender, and the first to provide systematic teaching of law, architecture and medicine. UCL is the seventh-ranked university in the 2008 THES-QS World University Rankings, and the third ranked UK university in the 2008 league table of the top 500 world universities produced by the Shanghai Jiao Tong University. UCL alumni include Marie Stopes, Jonathan Dimbleby, Lord Woolf, Alexander Graham Bell, and members of the band Coldplay. UCL currently has over 12,000 undergraduate and 8,000 postgraduate students. Its annual income is over £600 million.

About UCL Business PLC

UCL Business PLC (UCLB) is responsible for commercializing research across all disciplines generated from within UCL and associated organizations. It is primarily responsible for protecting inventions and transacting commercial activity including options, licences and collaborative commercial research. UCLB also has responsibility for creating and spinning-out companies from UCL. UCLB is wholly-owned by UCL and operates with its own Board of Directors.

DISCLOSURE NOTICE: The information contained in this release is as of April 24, 2009. Pfizer assumes no obligation to update any forward-looking statements contained in this release as the result of new information or future events or developments.

This release contains forward-looking information that involves substantial risks and uncertainties about an agreement with the goal of developing stem-cell-based therapies for certain ophthalmic conditions. Such risks and uncertainties include, among other things, the uncertainties inherent in research and development; decisions by regulatory authorities regarding whether and when to approve any drug applications that may be filed for any product candidates that may result from this agreement as well as their decisions regarding labeling and other matters that could affect their availability or commercial potential; and competitive developments.

A further description of risks and uncertainties can be found in Pfizer’s Annual Report on Form 10-K for the fiscal year ended December 31, 2008 and in its reports on Form 10-Q and Form 8-K.

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