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Inflammation & Remodeling

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The Inflammation & Remodeling research unit's goal is to discover and develop novel and differentiated therapeutic options targeting chronic inflammatory diseases. Chronic inflammation can result from sensing and integrating injury or danger signals including for example infectious agents, free radicals and oxidative stress. The unit focuses on three mechanistic themes each defining a distinct intervention point in the cycle of disease chronicity. The three mechanistic areas include: 1) epithelial, endothelial and parenchymal sensors of danger signals and the engagement of the innate immune system; 2) integrators and amplifiers of inflammation including cell signaling, chemotaxis, production of inflammatory mediators by various cell types and disruption of the mucosal / microbiome barrier surface; and 3) targeting tissue remodeling and fibrosis by regulating TGFB signaling, matrix stiffness, and fibroblast proliferation.

WRD is interested in establishing alliances to develop therapeutics, expand disease biology understanding, and identify biomarkers that impact:

  • Diabetic nephropathy
  • IgA nephropathy, Lupus nephritis and membranous nephropathy
  • Autosomal dominant polycystic kidney disease
  • Acute kidney injury
  • COPD
  • Severe asthma
  • Pulmonary vascular disease
  • Advanced wound care and skin disease

Specific areas of interest include:

  • Innate immune suppressors
  • Oxidative stress modulators
  • Anti-fibrotics
  • Technology platforms and products to help understand patient segmentation in the disease areas of interest

Not actively seeking partnering opportunities in:

  • Corticosteroids
  • Bronchodilators
  • ACE / ARB

 

R & D Brochure

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Understand what R&D is looking for in an early stage opportunity.

 

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