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Precision Medicine

precision-medicine

Precision Medicine is an approach to discovering and developing medicines and vaccines that deliver superior outcomes for patients, by integrating clinical and molecular information to understand the biological basis of disease. This effort leads to better selection of disease targets and identification of patient populations that demonstrate improved clinical outcomes.

WRD is interested in establishing alliances to develop and access:

  • Patient cohorts with high quality longitudinal molecular and phenotypic data and/or DNA and appropriately-consented, IRB-approved tissue samples for:
    • clinical trials
    • data mining
    • biomarker studies
    • genetic and pharmaco-genomic studies
  • Systems Biology/Pharmacology
    • Databases with high quality treatment and disease outcomes associated with genetic, metabolomic, proteomic, transcriptomic or epigenetic data
    • Databases of searchable eQTLs, pQTLs across tissues
    • Disease biology guided combination therapy design platforms
    • Systems biology approaches and proven in silico tools to evaluate pharmacological perturbation and elucidate mechanisms of in vivo toxicity
    • Mining of data for correlation and understanding of causality
  • Breakthrough diagnostic technologies that also are highly quantitative, require minimal tissue and can be multiplexed.
  • In vivo imaging technologies (including MRI, PET, CT, optical imaging technologies, imaging agents, genetically encoded tags, etc.) with particular interest in:
    • Imaging agents for small and large molecule compound distribution studies
    • Imaging agents monitoring physiological mechanisms and disease
    • Analytical tools and technologies
  • Ex vivo Tissue and Cell Analysis
    • Circulating tumor cell and Nucleic Acid quantification and analysis
    • Multiplexed flow cytometry for leukocyte analysis
    • Automated IHC for tissue analysis (cancer, safety)
    • Advanced ADME — related genotyping
  • Physiological Biomarkers
    • Technologies adding precision to pain management and treatment in pre-clinical and clinical studies
    • EEG-based biomarker for assessment of central pharmacology
  • iPS cell resources and technologies to generate iPS cells that may be used to enable Precision Medicine strategies
    • Validated cell differentiation protocols
    • iPS cells derived from sub populations with specific genotypic/phenotypic data
    • Technology to create iPS cells in a rapid and reproducible fashion without insertional approaches

R & D Brochure

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Understand what R&D is looking for in an early stage opportunity.

 

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