Biologics Product & Process Development
WRD Pharmaceutical Sciences envisions a network of strategic partnerships integral to its biologics technology initiatives, which include biopharmaceutical and vaccine development and manufacturing and prokaryotic expression to augment core competencies.
I. WRD is interested in establishing alliances to develop and access:
- Microbial and mammalian cell protein production systems for development purposes
- High-throughput expression, screening, and purification of proteins and antibodies for discovery purposes
Specific areas of interest include:
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For development purposes:
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Flexible approach to microbial process development and manufacturing
- One size fits all secretion system, preferably yielding soluble form of product and tolerant of cysteine linkages
- Automated methods for mammalian cell line screening, selection and scale up
- High throughput analytics for product quality attributes
- Analytics for glycoconjugates
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Flexible approach to microbial process development and manufacturing
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For discovery purposes:
- New expression systems with alternative post-translational modifications (e.g., glycosylation)
- Novel technologies related to protein fusion partners, co-expression of chaperone proteins, etc., that would improve expression and solubility of membrane-bound proteins
II. WRD is interested to ensure commercial and clinical differentiation of products by accessing leading drug delivery technologies.
Specific areas of interest include:
- Innovative injection devices
- Technologies for half life extension
- Alternative routes of delivery (transdermal, transmucosal)
- Advanced formulations ( improved stability, high dose delivery)
Not actively seeking partnering opportunities in:
- Transgenic animal-based or plant-based production systems for biologics
