Immunology & Inflammation
Our goal is to transform chronic inflammatory diseases, many of which are poorly managed by existing treatments that only provide symptom relief, at best. We seek to address the root cause of this inflammation at a molecular level and develop first-in-class or best-in-class medicines. We continue to advance Pfizer’s leading science on the JAK pathway, developing tailored therapies targeting specific aspects of the JAK pathway in key autoimmune diseases such as lupus.
Pfizer is also advancing programs targeting inflammation in the lung and kidneys, where environmental or internal “danger signals” in the body trigger inflammatory responses that can lead to chronic kidney disease, chronic obstructive pulmonary disease (COPD). Key to our approach is re-engaging the body’s innate immunity and key pathways of tissue remodeling and fibrosis.
Longer-term, we are increasingly studying the potential to reset immune system homeostasis by targeting immunoregulation.