Psychoses

• Bipolar and Cognition
• Schizophrenia
• Neuroscience Discovery

Bipolar and Cognition

Areas of Partnering Interest

• Maintenance and relapse prevention of mania and depression in bipolar
• Rapid onset treatment of bipolar depressive symptoms
• Improved animal models, modeling cycling or manic/depressive symptoms
• Molecular profiling (both preclinical models and with clinical samples) to better understand mechanisms underlying treatment response
• Bipolar diagnostic to differentiate bipolar disorder from schizophrenia and depression
• Translatable biomarker predictive of clinical outcome, with focus on imaging/early efficacy or EEG

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Schizophrenia

Areas of Partnering Interest

• Novel mechanisms for schizophrenia monotherapy
• Novel mechanisms to improve cognition and negative symptoms in schizophrenia
• Technology/methodology for cognition enhancement efficacy signal detection for schizophrenia
• Growth factor deficiencies in schizophrenia
• Validated/robust animal models of cognitive and negative domains impacted in schizophrenia
• Electrophysiology/imaging in animals with potential for translatable biomarker
• Animal models of speed of processing deficits
• Animal model of Gamma Aminobutyric Acid (GABA) interneuron de-differentiation
• Cognitive deficits in schizophrenia
• Schizophrenia: disease modification

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Neuroscience Discovery

Areas of Partnering Interest

• Predictive animal models
• Across all neuroscience disease areas
• Speed of processing defects, interneuron de-differentiation, depressive symptoms
• Pharmacodynamic models of central activity; models with reporters of central activity
• Pharmacologically validated disease
  relevant assays
• Genetically modified animals with reporters of central activity for in vivo imaging
• Human disease models
• Genome scans/sub-typing human disease populations
• Understanding the science underlying disease progression/molecular profiling
• Pharmacodynamic models, disease
  relevant assays
• Translatable biomarkers/diagnostic
• Predictive of cognitive functional outcomes, imaging
• Stratify responders/non-responders
• Pre-symptomatic testing, enhanced diagnosis, clinical assessments
• Technology
• 3D microanatomy of amyloid plaques and mitochondria
• High throughput measures of hippocampal neurogenesis and synaptogenesis

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Kelly Longo
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