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How Does a Protease Inhibitor Work

The FDA has authorized Pfizer’s COVID-19 oral treatment for emergency use. This is a potentially game-changing therapy that could change the way we treat COVID-19, and represents a tremendous example of how science could help defeat this pandemic. 

This at-home treatment can be prescribed to high-risk patients, 12 years of age and older weighing at least 40 kg (88 lbs), who tested positive for COVID-19 — potentially helping patients avoid severe illness and reducing hospitalizations and deaths from COVID-19.  

The pill is a protease inhibitor, which blocks the activity of a key enzyme that the coronavirus needs in order to replicate.

Follow the science and see how it works here:

Pfizer's oral treatment has not been approved, but has been authorized for emergency use by the FDA to treat mild-to-moderate COVID-19 in patients 12 and older, weighing at least 40 kg, with positive results of SARS-CoV-2 viral testing, who are at high risk for progression to severe COVID-19, including hospitalization and death. Authorized only for the duration of the declaration that circumstances exist justifying the authorization unless the declaration is terminated or authorization revoked sooner. See EUA Fact Sheet: