Evidence-Based Evaluation of Antibiotic Drug Allergy in the Inpatient Setting
This pilot study addresses a significant practice gap in the management of purported penicillin allergy in hospitalized patients. Up to 90% of listed penicillin allergies are invalid; prior data suggest such patients have longer hospital stays, higher rates of resistant nosocomial infections, greater healthcare utilization, and even higher mortality; and a validated and reliable testing method exists; yet, no interventional testing protocol has been implemented on a large scale for inpatient testing. In this study, we will test the feasibility and impact of implementing evidence-based penicillin allergy testing guidelines on a hospital-wide level among patients admitted to our hospital with penicillin allergy. Demonstrable improvements in utilization of broad-spectrum antibiotics, healthcare cost, nosocomial infections, length of stay, mortality, and other metrics as a result of this pilot study may enable implementation of this protocol as an ongoing quality improvement measure at our institution and other major health systems.
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