- Adults patients with rheumatoid arthritis
- Patients who have received stable weekly doses of oral methotrexate (5 to 25 mg/week
administered as a single dose) for a minimum of 28 days (4 weeks/4 doses)
- History of chronic infectious disease such as genitourinary, pulmonary or sinus
infections.
- Any current or known malignancy or history of malignancy within the previous 5 years
- Pregnant or lactating women; women of child-bearing potential who are unwilling to
unable to use an acceptable method of birth control during the study