- Healthy, ambulatory men and women (of non-childbearing potential) ages 18 -70
- Baseline total cholesterol ≥ 200 mg/dl, baseline LDL ≥ 130 mg/dl.
- BMI 18.5 to 35, and body weight ≤150 kg, inclusive.
- Evidence of clinically significant disease that may increase the risk to the subject
of study participation or interfere with interpretation of results.
- Secondary hyperlipidemia.
- Subjects who have taken lipid lowering compounds within the past 12 months prior to