Study To Evaluate Efficacy And Safety Of An Additional Dose Of Celecoxib (YM177) In Patients With Post-Tooth Extraction Pain

• Drug: Celecoxib
  
  Initial dose: Celecoxib 200mg tablet x 2 will be administrated during a period from 1 to 2 hours post lateral mandibular impacted third molar tooth extraction in subjects with "moderate pain" or "severe pain"rated as 45.0 mm or more on the VAS
• Drug: Celecoxib
  
  Additional dose: Celecoxib 200mg tablet x 1 will be administrated during a period from 5 to 12 hours post-initial dose of Celecoxib 400mg in subjects who require an additional analgesic dose for any pain
• Drug: Placebo
  
  Additional dose: Placebo (tablet) will be administrated during a period from 5 to 12 hours post-initial dose of Celecoxib 400mg in subjects who require an additional analgesic dose for any pain

• Experimental: Celecoxib 400mg
  
  Intervention: Drug: Celecoxib
• Experimental: Celecoxib 200mg
  
  Intervention: Drug: Celecoxib
• Placebo Comparator: Placebo
  
  Intervention: Drug: Placebo

Inclusion Criteria:

Initial dose:

• 20 to 64 years
• Patients with undergoing mandibular impacted third molar tooth extraction accompanied by lateral bone removal and crown cutting
• Patients with pain that meets both of the following criteria
• Pain intensity (4-categorical): "moderate pain" or "severe pain"
• Pain intensity (VAS): 45.0 mm or more

Additional dose:

• Patients with pain that corresponds to "4. Agree" or "5. Strongly agree" as the answer to the "question about the pain intensity" during the period from 5 hours to 12 hours post-initial dose of the study drug

Exclusion Criteria:

• Patients with acute inflammatory findings in the oral cavity necessitating treatment
• Patients who are scheduled to receive general anesthesia and analgesics in the process of the eligible tooth extraction