A Study To Assess The Safety And Tolerability Of Different Doses Of PF-06444753 And PF-06444752 In Subjects With Allergic Rhinitis

• Biological: IGE-1
  
  Intramuscular, multiple dose
• Biological: IGE-2
  
  Intramuscular, multiple dose
• Biological: Saline
  
  Saline (0.9% sodium chloride)

• Experimental: PF-06444753
  
  Intervention: Biological: IGE-1
• Experimental: PF-06444752
  
  Intervention: Biological: IGE-2
• Placebo Comparator: Placebo
  
  Intramuscular
  Intervention: Biological: Saline

Inclusion Criteria:

• Healthy, males or females of non-child bearing potential, who are between 18 and 55 years, inclusive,
• Intermittent or persistent allergic rhinitis that is associated with perennial or seasonal allergen reactivity at screening as determined by a positive specific IgE level ?1 KU/L to at least one of the following common allergens: dust mite (Dermatophagoides farinae or Dermatophagoides pteronyssinus), cat, dog, mold (Alternaria), Bermuda grass, common ragweed, oak, Timothy grass or elm.

Exclusion Criteria:

• Evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, or neurologic disease that may compromise their ability to safely participate in the study.
• Evidence or history of clinically significant pulmonary disease (including allergic and non-allergic asthma, chronic obstructive pulmonary disease [COPD], cystic fibrosis, bronchiectasis, chronic bronchitis, emphysema, tuberculosis, pulmonary fibrosis, pulmonary hypertension, or others).
• Evidence or history of clinically significant autoimmune disease (including rheumatoid arthritis, systemic lupus erythematosus, ulcerative colitis, or others).