ABOUT THIS STUDY
FOR MORE INFORMATION
Contact a representative by phone, email, or visiting the study website. Please see the references below:
Pfizer Clinical Trials Contact Center
1-800-718-1021
- Prior to participation in this study, each prospective study individual must sign an informed consent form.
- Diagnosis of probable or possible Alzheimer's disease according to NINDS-ADRDA and DSM-IV criteria.
- Not actively participating in another clinical drug trial.
- MMSE range 12-28 at entry.
- Hachinski Modified Ischemic score < or =4.
- Accompanied by appropriate caregiver who can aid in administration of medication and make assessments.
- Good general health as evidenced by physical, neurological and clinical laboratory examination.
- Education level > or = 9th grade or equivalent.
- Fluent in the English language.
- Reliable caregiver.
- Able to complete neuropsychological tests.
- Ambulatory.
- On stable doses of medications for the treatment of non-excluded medical conditions for four weeks prior to screening.
- Able to participate in all scheduled evaluations.
- Geriatric Depression Scale < or = 20.
- Not exceeding 400 IU of Vitamin E for 30 days.
- For patients currently taking donepezil, they must remain on a stable dose for at least three months. Individuals taking stable doses of other cholinesterase inhibitors can be included, but no study subject may initiate use of any cholinesterase inhibitor after entrance to trial.
- Individuals of both sexes over 50 years of age will be eligible.
- Significant neurological or psychiatric disease other than Alzheimer's disease.
- Patients with known or suspected Parkinsons's disease or dementia with Lewy bodies.
- Significant systemic illness (including uncontrolled hypertension) or organ failure.
- History of mental illness within one year or history of significant untreated cardiac
or thromboembolic vascular disease (arrythmias, unstable angina, CVA, deep venous
thrombosis, or pulmonary embolus).
- Current chronic use of anti-cholinergic medications (anti-histamines, and Artane or
Cogentin). Stable doses of anxiolytics, sedatives, hypnotics, antipsychotics and SSRI
antidepressants are acceptable. The use of any antipsychotics or tricyclic
anti-depressants must be reviewed prior to entry.
- Diagnosis of major depression according to DSM-IV criteria in the last two years.
- Allergies to atorvastatin or HMG CoA reductase inhibitors.
- Pregnant women.
- History of head injury.
- On a cholesterol lowering drug at time of enrollment.
- History of significant liver disease and or elevated transaminases.
- Cholesterol level lower than 90 mg% at initial screening
NEED INFO?
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Descriptive Information | ||||
---|---|---|---|---|
Brief Title ICMJE | Lipitor as a Treatment for Alzheimer's Disease | |||
Official Title ICMJE | Effect of the HMG-CoA Reductase Inhibitor Atorvastatin Calcium, Lipitor, in the Treatment of Alzheimer's Disease | |||
Brief Summary | The purpose of this study is to assess the clinical benefit of Lipitor, a cholesterol-lowering drug, in the treatment of Alzheimer's disease. | |||
Detailed Description | This study is a phase II, placebo controlled, double-blind, one year trial investigating the effect of HmG-CoA reductase inhibitor atorvastatin calcium in the treatment of persons with possible or probable Alzheimer's disease. Subjects may continue to take stable doses of Aricept and Exelon. Following enrollment, participants will make visits to the study center every three months for blood tests and neuropsychological testing. | |||
Study Type ICMJE | Interventional | |||
Study Phase ICMJE | Phase 2 | |||
Study Design ICMJE | Allocation: Randomized Masking: Double Primary Purpose: Treatment | |||
Condition ICMJE | Alzheimer Disease | |||
Intervention ICMJE | Drug: Atorvastatin calcium | |||
Study Arms ICMJE | Not Provided | |||
Publications * |
| |||
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline. | ||||
Recruitment Information | ||||
Recruitment Status ICMJE | Completed | |||
Enrollment ICMJE | 98 | |||
Original Enrollment ICMJE | Same as current | |||
Study Completion Date ICMJE | August 2004 | |||
Primary Completion Date | Not Provided | |||
Eligibility Criteria ICMJE | Inclusion Criteria:
Exclusion criteria:
| |||
Sex/Gender ICMJE |
| |||
Ages ICMJE | 50 Years and older (Adult, Older Adult) | |||
Accepts Healthy Volunteers ICMJE | No | |||
Contacts ICMJE | Contact information is only displayed when the study is recruiting subjects | |||
Listed Location Countries ICMJE | United States | |||
Removed Location Countries | ||||
Administrative Information | ||||
NCT Number ICMJE | NCT00024531 | |||
Other Study ID Numbers ICMJE | IA0031 | |||
Has Data Monitoring Committee | Not Provided | |||
U.S. FDA-regulated Product | Not Provided | |||
IPD Sharing Statement ICMJE | Not Provided | |||
Responsible Party | Not Provided | |||
Study Sponsor ICMJE | Institute for the Study of Aging (ISOA) | |||
Collaborators ICMJE | Pfizer | |||
Investigators ICMJE |
| |||
PRS Account | National Institute on Aging (NIA) | |||
Verification Date | November 2006 | |||
ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP |