- Histologically/cytologically confirmed adenocarcinoma of the breast, followed by
adequate surgical resection and/or radiotherapy, and/or adjuvant chemotherapy, if
indicated.
- Stage T1-3 N0-2 Mo, Any TNM stage BC for whom adjuvant hormonal therapy is being
considered.
- Those patients not deemed to have had potentially curative primary surgical treatment
or one of the following criteria:
- Inflammatory breast cancer
- Histologically positive supraclavicular nodes
- Ulceration/infiltration of local skin metastasis
- Neoadjuvant chemotherapy
- Ductal carcinoma in situ (DCIS) or lobular carcinoma in situ (LCIS) without invasion
- ER and PR negative primary tumor or ER/PR unknown status.