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Capravirine (AG1549) in Combination With Viracept and Two NRTIs in HIV Infected Patients Who Failed an Initial NNRTI Containing Regimen

Last updated on February 21, 2019

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Study Location
Pfizer Investigational Site
Beverly Hills, California, 90211 United States
Contact
1-800-718-1021
Eligibility criteria
Condition
The disease, disorder, syndrome, illness, or injury that is being studied.
Human Immunodeficiency Virus
Sex
Females and Males
Age
Pediatric Trials: 0-17 Years
Adult Trials: 18+ Years
18 + years
Inclusion criteria
The factors, or reasons, that allow a person to participate in a clinical study.
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- Male or female at least 18 years old

- HIV RNA level >1000 copies/mL at screening

- CD4 >50 cells/uL at screening

- Patient is currently taking a regimen that includes an NNRTI plus 2 NRTIs for at least
28 days and is currently failing this regimen

- Patient has adequate hematology tests (absolute neutrophil count >1000/uL,
Platelets>75,000uL, hemoglobin 9g/L)

- Patient has adequate renal function (serum creatinine of

- Patient has adequate liver function (AST, ALT, and bilirubin normal)

Exclusion criteria
The factors, or reasons, that prevent a person from participating in a clinical study.
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- Previous use of protease inhibitors (except if patient has short duration of PI and
was switched for tolerability reasons when viral load was does not include Viracept

- Women who are pregnant or lactating

NCT00051844
Pfizer
Completed
Capravirine (AG1549) in Combination With Viracept and Two NRTIs in HIV Infected Patients Who Failed an Initial NNRTI Containing Regimen

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