- Male or female at least 18 years old
- HIV RNA level >1000 copies/mL at screening
- CD4 >50 cells/uL at screening
- Patient is currently taking a regimen that includes an NNRTI plus 2 NRTIs for at least
28 days and is currently failing this regimen
- Patient has adequate hematology tests (absolute neutrophil count >1000/uL,
Platelets>75,000uL, hemoglobin 9g/L)
- Patient has adequate renal function (serum creatinine of
- Patient has adequate liver function (AST, ALT, and bilirubin normal)
- Previous use of protease inhibitors (except if patient has short duration of PI and
was switched for tolerability reasons when viral load was
does not include Viracept
- Women who are pregnant or lactating