- Poor prognosis AML or MDS
- Histological confirmation of diagnosis
- White blood cell count less than or equal to 30,000/mm3
- Adequate hepatic and renal function documented within 14 days prior to registration
- Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2
- No evidence of preexisting uncontrolled hypertension
- Not a suitable candidate for chemotherapy
- No prior systemic chemotherapy treatment for AML or MDS or treatment with an
anti-angiogenesis agent
- Patients must not have exclusion criteria.
- Candidate for chemotherapy
- Patients with AML M3 (acute promyelocytic leukemia)
- Conditions that might confound the evaluation of safety or efficacy or increase
patient risk.