- Current symptoms consistent with mild to moderate heart failure (NYHA functional class
II and III)
- LVEF (left ventricular ejection fraction) of screening
- Therapy with an angiotensin converting enzyme inhibitor (ACEI) or angiotensin receptor
blocker (ARB) and beta-blocker (BB) (unless documented intolerance) for at least 3
months duration and at dose that has not been adjusted within the previous 4 weeks
- Current decompensated heart failure or heart failure hospitalization or severe heart
failure (NYHA functional class IV) within 6 months of screening
- Use of eplerenone or spironolactone within 30 days of randomization or for more than 7
days within the previous 6 months