Eligibility criteria
Condition
Renal Cell Carcinoma
Sex
Females and Males
Age
18 + years
Inclusion criteria
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- Histologically proven renal cell carcinoma of clear cell histology with metastases
- Evidence of measurable disease
- Radiographic evidence of disease progression during or within 3 months of completion
of bevacizumab-based treatment
- Prior radical or partial nephrectomy
Exclusion criteria
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- Prior treatment with any other anti-angiogenic therapy other than bevacizumab
- Prior systemic treatment for RCC > 2 regimens
- History of or known brain metastases
- Serious acute or chronic illness or recent history of significant cardiac abnormality