- Male and/or female subjects without clinically relevant abnormalities identified by a
detailed medical history, full physical examination, including blood pressure and
pulse rate measurements, 12 lead ECG and clinical laboratory tests
- Body Mass Index (BMI) ³30 and
- co morbidities; BMI ³27 kg/m2 and
[history of essential hypertension and/or dyslipidemia defined as high LDL (³160
mg/dL) or high total cholesterol (³240 mg/dL)];
- Subjects with resting sitting systolic blood pressure of 140 mmHg or greater or
diastolic blood pressure of 90 mmHg or greater.
- Subjects with type 2 diabetes or fasting blood glucose concentration ³126 mg/dL;
- Subjects with a history of eating disorders like anorexia nervosa or bulimia nervosa
- Subjects on prescription and non-prescription appetite or weight modifying drugs