- A history of nickel allergy confirmed by a visual positive reaction (graded at least
++) to T.R.U.E. TEST.
- Subjects with evidence or history of clinically significant hematological, renal,
endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric,
neurologic, or allergic disease (including drug allergies, but excluding contact
allergic dermatitis or untreated, asymptomatic, seasonal allergies at time of dosing).