- Histologically confirmed malignant solid tumor that has progressed following standard
therapy, or for which no standard effective treatment is available
- Tumor expression of Lewis Y antigen ( > or = 20% tumor cells positive for Lewis Y by
immunohistochemistry assay)
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- Chemotherapy, radiation therapy, other cancer therapy, or investigational agents
within 21 days of the first dose of CMD-193 (42 days if the previous chemotherapy
included nitrosoureas or mitomycin C)
- Symptomatic or clinically active CNS metastases. Subjects who have had prior treatment
with radiotherapy or surgical resection for CNS metastases will be permitted if CNS
metastases have remained stable and have not required any treatment for at least 3
months prior to the first dose of CMD-193.
- Significant prior allergic reaction to recombinant human or murine proteins