- Healthy women aged 18 to 49 years
- Regular 21 to 35 day menstrual cycles for 3 months prior to study visit 1
- History of menstrual cycle related symptoms as determined by the investigator.
- Contraindication to combination oral contraceptives
- Depression requiring hospitalization or associated with suicidal ideation within the
last 3 years
- Use of antidepressants/anxiolytics within 10 days of screening and for the duration of