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Donepezil in the Prevention of Post-Operative Cognitive Decline

Last updated on March 14, 2019

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Study Location
University Hospital, Clarian Health Partners
Indianapolis, Indiana, 46202 United States
Contact
1-800-718-1021
Eligibility criteria
Condition
The disease, disorder, syndrome, illness, or injury that is being studied.
Postoperative Complications, Delirium
Sex
Females and Males
Age
Pediatric Trials: 0-17 Years
Adult Trials: 18+ Years
65 + years
Inclusion criteria
The factors, or reasons, that allow a person to participate in a clinical study.
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- Community-dwelling individuals aged 65 or older

- Scheduled for elective hip or knee replacement at University Hospital

- Mild cognitive impairment, defined as:

- MMSE total score of 27 or less;

- normal performance of the activities of daily living tasks of the Bristol scale
after excluding mobility related difficulties;

- no chart-based dementia diagnosis; and

- no history of ever being on dementia medications such as Memantine or any
cholinesterase inhibitors

- Consent to participate in the study

Exclusion criteria
The factors, or reasons, that prevent a person from participating in a clinical study.
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- Chart-based dementia diagnosis

- MMSE score greater than 27

- Difficulty performing the activities of daily living not related to mobility as
measured by the Bristol scale

- Current or past history of receiving dementia medications such as Memantine or any
cholinesterase inhibitors (Tacrine, Donepezil, Rivastigmine, or Galantamine)

- Metastatic cancer or other comorbid illnesses likely to reduce life expectancy to
under 6 months

- Multiple trauma or pathological fractures requiring acute hip or knee replacement

- Aphasic, blind, or deaf

- Use of neuroleptics one month prior to surgery

- Allergy to donepezil

- Inability to read and complete study tests and forms

- Alcohol or drug dependence, defined as intake of more than 5 units of alcohol daily
during the past 3 months

- Not expected to be discharged from hospital or able to complete the 3-month
postoperative test

- Not competent to make medical decisions

NCT00182845
Pfizer
Completed
Donepezil in the Prevention of Post-Operative Cognitive Decline

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