Eligibility criteria
Condition
Premenstrual Syndrome, Menstruation Disturbances
Sex
Female
Age
18-49 years
Inclusion criteria
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- Generally healthy, women aged 18 to 49 years.
- History of severe PMS symptoms over the last year, as determined by the investigator.
- Regular 21 to 35 day menstrual cycle for 2 months prior to first study visit.
Exclusion criteria
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- Major depressive disorder requiring antidepressant treatment or hospitalization within
the last 3 years.
- Contraindication to combination oral contraceptives.
- Use of antidepressants/anxiolytics within 10 days of screening and for the duration of
the study.
Other exclusion applies.