ABOUT THIS STUDY
- Patients: Men and women between the ages 18 to 55 who meet the ICD-10 criteria for schizophrenia living in the catchment area of the psychiatric departments of Bispebjerg University Hospital, Psychiatric Center, Glostrup and Rigshospitalet. Patients can be either unmedicated, or need to be switched from other antipsychotic medications due to side-effects, or lack of effect on negative symptoms, positive symptoms, or cognitive function.
- Controls: Healthy men and women matched according to gender, age, and socio-economic status (determined by the level of education and income of parents).
- Patients: Patients hospitalized against their will. Patients with a serious medical
illness or with laboratory abnormalities, where pharmacotherapy poses a substantial
clinical risk; pregnant or lactating patients; patients with organic psychosis, a
history of severe head trauma or convulsive disorders, or patients with mental
retardation. Patients with significant alcohol- or drug dependence are excluded.
- Controls: Pregnant or lactating women; a history of severe head trauma; mental
retardation; learning difficulties; a history of psychiatric illness or a familial
predisposition to psychiatric illness (in first-degree relatives); significant
alcohol- or drug dependence; episodic incidents of excessive alcohol consumption or
drug abuse are not reasons for exclusion. Abuse is monitored by interviewing patients
and by measuring the urine content for amphetamine, cannabinoles, opiates, and
benzodiazepines. Concomitant use of benzodiazepines for agitation or insomnia
(oxazepam up to 45 mg daily) is allowed when needed and when used conservatively
during the trial. Use of anticholinergic compounds is not allowed.
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