- Diagnosis of chronic bronchitis (chronic cough and sputum production on most days for
three consecutive months for more than two consecutive years) and clinical evidence of
AECB as demonstrated by both the following symptoms:
- Production of purulent sputum as defined by Gram stained sputum specimen
- Presence of all of the following:
- Increased sputum production
- Increased dyspnea
- Increased cough
- At least two exacerbations of AECB in the past 12 months
- Documented FEV1 less than 80% of predicted
- A chest radiograph consistent with pneumonia
- Treatment with any systemic antibiotic within the twenty-one days prior to study entry
or those with a chance of receiving other systemic antibiotics during study
participation