Safety And Efficacy Of Ziprasidone In Adolescents With Schizophrenia

• Drug: placebo
  
  Placebo matching the oral ziprasidone capsules of 20 mg, 40 mg, 60 mg, and 80 mg strength or matching placebo. Subjects will be dosed daily for 6 weeks using a flexible dose design with a minimal dose range of 40mg twice a day (BID) to a maximum dose range of 80 mg BID. For subjects weighing <45 kg, the doses will range from 20 mg BID to 40 mg BID.
• Drug: Ziprasidone oral capsules
  
  Oral ziprasidone capsules of 20 mg, 40 mg, 60 mg, and 80 mg strength or matching placebo. Subjects will be dosed daily for 6 weeks using a flexible dose design with a minimal dose range of 40mg BID to a maximum dose range of 80 mg BID. For subjects weighing <45 kg, the doses will range from 20 mg BID to 40 mg BID.
  Other Name: Geodon, Zeldox

• Placebo Comparator: 2.0
  
  Intervention: Drug: placebo
• Active Comparator: 1.0
  
  Intervention: Drug: Ziprasidone oral capsules

Inclusion Criteria:

• Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) criteria for schizophrenia: Current symptoms were to be present for at least 7 days before screening.
• At the Screening and Baseline visits, subjects must have had a Brief Psychiatric Rating Scale - Anchored score ?35 and a score of ?4 on at least 1 of the following items: unusual thought content (i.e., delusions), hallucinations, suspiciousness, or conceptual disorganization.
• Age 13 - 17 years

Exclusion Criteria:

• Imminent risk of suicide or homicide, as judged by the site investigator
• Any history of serious or unstable medical illness, including risk for QT prolongation