Eligibility criteria
Condition
Kidney Neoplasms, Renal Cell Carcinoma
Sex
Females and Males
Age
18 + years
Inclusion criteria
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- RCC with metastases and nephrectomy
- failure of prior sorafenib-based therapy
- at least 1 target lesion that has not been irradiated
- adequate bone marrow, hepatic and renal function, > or equal to 18 years of age.
Exclusion criteria
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- Gastrointestinal abnormalities
- current use or inability to avoid chronic antacid therapy
- current use or anticipated inability to avoid potent CYP3A4 inhibitors or CYP1A2
inducers
- active seizure disorder or evidence of brain metastases.