- Subjects will be current cigarette smokers who have smoked an average of at least 10
cigarettes per day during the past year and during the month prior to the screening
- mild to moderate COPD confirmed by spirometry
- Subjects must have a clinical diagnosis of COPD.
- Subjects who have made a serious attempt to quit smoking in the past 3 months.
- Subjects who have been previously randomized in a study that has included varenicline.