- Healthy men and women between 18 to 55 years of age
- Healthy as determined by the investigator on the basis of medical history and physical
examination, laboratory test results, vital signs, and no clinically significant
abnormalities on 12-lead electrocardiogram (ECG)
- History of nonsmoker for at least 1 year
- Presence or history of any disorder or significant cardiovascular, hepatic, renal,
respiratory, gastrointestinal, endocrine, immunologic, dermatologic, hematologic,
neurologic, any severe conditions of the ears, eyes or throat (such as glaucoma or
increased intraocular pressure), or psychiatric disease that may prevent the
completion of the study
- Known or suspected alcohol abuse or consumption of more than 2 standard units per day
within past 6 months or known or suspected abuse of prohibited drugs or other
substances
- Use of any over-the-counter, prescription, hormonal therapy or investigational
medications within 30 days of study day -1 until the end of the study