plaque psoriasis involving greater than or equal to 10% of the body surface and a minimum
Psoriasis Area and Severity Index (PASI) score of 10 at screening. -Failure to respond to,
or have a contraindication to, or intolerant to at least 1 of the following systemic or
phototherapies at an adequate dose of sufficient duration: Methotrexate (MTX), Acitretin,
Cyclosporine, Ultraviolet A (UVA), Ultraviolet B (UVB), Psoralen and Ultraviolet A (PUVA),
TNF inhibitors. -Active guttate, erythrodermic, or pustular psoriasis at the time of the
screening or baseline.