1. Aged 2 months (42 through 98 days) at the time of enrollment.
2. Available for the entire study period and whose parent(s)/legal guardian(s) could be
reached by telephone.
3. In good health as determined by medical history, physical examination, and judgment of
4. Parent(s)/legal guardian(s) were able to complete all relevant study procedures during
1. Previous vaccination with licensed or investigational pneumococcal vaccine.
2. Previous vaccination with Hib conjugate, diphtheria, tetanus, pertussis, or polio
3. A previous anaphylactic reaction to any vaccine or vaccine-related component.
4. Contraindication to vaccination with Hib conjugate, diphtheria, tetanus, pertussis,
polio, hepatitis B, or pneumococcal vaccines.
5. Bleeding diathesis or condition associated with prolonged bleeding time that would
contraindicate intramuscular injection.
6. Known or suspected immune deficiency or suppression.
7. History of culture-proven invasive disease caused by S pneumoniae.
8. Major known congenital malformation or serious chronic disorder.
9. Significant neurological disorder or history of seizure (including febrile seizure),
or significant stable or evolving disorders (such as cerebral palsy, encephalopathy,
or hydrocephalus), or other significant disorders. This did not include resolving
syndromes because of birth trauma such as Erb palsy.
10. Receipt of blood products or ?-globulin (including hepatitis B immunoglobulin and
monoclonal antibodies [eg, Synagis]).