Azithromycin Plus Chloroquine Versus Mefloquine In the Treatment of Uncomplicated P. Falciparum Malaria.

• Drug: Azithromycin plus Chloroquine
  
  Azithromycin 1000 mg by mouth (PO) (two 500 mg tablets) once daily (QD) for 3 days(Days 0, 1, 2) plus chloroquine 600 mg base PO once daily for 3 days (Days 0, 1, 2)
  Other Name: Zithromax
• Drug: Mefloquine
  
  Mefloquine 1250 mg PO given as a split dose (750 mg [three 250 mg capsules]) initial dose followed by 500 mg PO (two 250 mg capsules) given 6 to 10 hours later on Day 0

• Experimental: 1
  
  Intervention: Drug: Azithromycin plus Chloroquine
• Experimental: 2
  
  Intervention: Drug: Mefloquine

Inclusion Criteria:

• Females and males 18 years of age and older with uncomplicated, symptomatic malaria as as indicated by the presence of both of the following:
• Blood smears positive for Plasmodium falciparum asexual parasitemia between 1000 -100,000 parasites
• Documented fever (38.5 C/101.3 F rectal or tympanic; 37.5 C/99.5 F axillary or 38 C/100.4 F oral) or history of fever (as reported by subject) within the prior 24 hours.

Exclusion Criteria:

• Severe or complicated malaria.
• Pregnant or breast-feeding women.