Male or non-pregnant female aged 40-75 with chronic moderate to severe knee pain due to OA
(scoring 50 out of 100 on a visual analog scale on knee pain).
Subjects must meet one of the following: unwilling to take non-opiate pain medications, or
for whom non-opiate pain medications have failed, or are candidates for or seeking invasive
interventions such as intraarticular injections, knee arthroplasty, or total knee surgery
History or symptoms of autoimmune disorders, cancer within the last 5 years except for
cutaneous basal cell or squamous cell cancer resolved by excision, allergic reaction to
monoclonal antibodies or IgG-fusion proteins, Hepatitis B, C or HIV, drug abuse,
fibromyalgia, clinically significant cardiac disease, diabetes mellitus requiring oral
treatment or insulin, clinically significant neurological disease or clinically significant
psychiatric disorders