Eligibility criteria
Condition
Glioma, Medulloblastoma
Sex
Females and Males
Age
6-18 months
Inclusion criteria
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- Cohort 1: Recurrent or refractory medulloblastoma in which current standard treatment
approaches have failed; biopsy is not required for recurrent disease.
- Cohort 2: Newly-diagnosed high-grade glioma (World Health Organization [WHO] grade 3
or 4)
- Life expectancy ≥ 3 months
Exclusion criteria
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- Diagnosis of brainstem glioma
- Concurrent administration of any other anti-tumor therapy
- Pre-existing uncontrolled diarrhea