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Study Comparing Etanercept 50 mg Once Weekly to 25 mg Twice Weekly in Patients With Ankylosing Spondylitis

Last updated on March 11, 2019

FOR MORE INFORMATION
Study Location
Contact
1-800-718-1021
Eligibility criteria
Condition
The disease, disorder, syndrome, illness, or injury that is being studied.
Ankylosing Spondylitis
Sex
Females and Males
Age
Pediatric Trials: 0-17 Years
Adult Trials: 18+ Years
18-70 years
Inclusion criteria
The factors, or reasons, that allow a person to participate in a clinical study.
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- Diagnosis of AS, as defined by Modified New York Criteria for Ankylosing Spondylitis.

- Active AS, defined by average of visual analog scale (VAS) of ≥ 30 for duration and
intensity of morning stiffness and at least 2 of the following: VAS for patient global
assessment ≥ 30; average of VAS for nocturnal and total pain ≥ 30; BASFI ≥ 30 (all
scores on a scale of 0 to 100).

Exclusion criteria
The factors, or reasons, that prevent a person from participating in a clinical study.
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- Complete ankylosis (fusion) of spine.

- Previous treatment with etanercept, antibody to Tumor Necrosis Factor ? (TNF?), or
other TNF? inhibitors or other biologic agents.

- Use of disease modifying antirheumatic drugs (DMARDs) other than hydroxychloroquine,
sulphasalazine, and methotrexate within 4 weeks of baseline. Subjects treated with
hydroxychloroquine, sulphasalazine, and methotrexate may continue these drugs during
this study but doses must be held stable for 4 weeks before baseline examination and
for the duration of the study.

- Receipt of multiple nonsteroidal anti-inflammatory drugs (NSAIDs) at baseline.

- Dose of NSAID changed within 2 weeks of baseline evaluation.

- Dose of prednisone >10 mg/day (or equivalent) or changed within 2 weeks of baseline
evaluation.

NCT00418548
Pfizer
Completed
Study Comparing Etanercept 50 mg Once Weekly to 25 mg Twice Weekly in Patients With Ankylosing Spondylitis

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Questions about a trial? Call or email to reach a Pfizer Clinical Trial Contact Center

Pfizer Clinical Trials Contact Center

1-800-718-1021

[email protected]

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FOR MORE INFORMATION

Contact a representative by phone, email, or visiting the study website. Please see the references below:

BY PHONE

Pfizer Clinical Trials Contact Center

1-800-718-1021

BY EMAIL

Contact

[email protected]

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