- Subject is 21 years of age or older
- Subject is either not of childbearing potential OR subject must use an acceptable
method of birth control if of childbearing potential
- Negative pregnancy test if female of childbearing potential
- Subject is in general good health
- Subject required treatment of joint pain within the last 90 days
- Subject has primary diagnosis of osteoarthritis (OA) of the hip or knee
- Subject has a documented history of allergic reaction or intolerance to morphine or
other opioids
- Subject is pregnant or breast-feeding
- Subject is receiving systemic chemotherapy
- Subject has a history of drug abuse/dependence/misuse or alcohol abuse/dependence
- Subject has history of major depressive disorder not controlled with medication
- Subject has any chronic pain syndrome (i.e., fibromyalgia) that may interfere with the
symptoms of OA
- Subject has active gastrointestinal disease, with the exception of gastroesophageal
reflux disease (GERD)
- Subject has a documented history of rheumatoid arthritis, uncontrolled inflammatory
arthritis or non-steroidal anti-inflammatory drug (NSAID)-dependent inflammatory
arthritis