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A Dose Finding Study Of PF-00489791 In Patients With Mild To Moderate High Blood Pressure

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NCT00422461

Last updated on May 10, 2018
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FOR MORE INFORMATION
Study Location
Pfizer Investigational Site
Los Angeles, California, 90057 United States
See other locations
Contact
1-800-718-1021
[email protected]
Related Links
Eligibility criteria
Condition
The disease, disorder, syndrome, illness, or injury that is being studied.
Hypertension
Sex
Females and Males
Age
Pediatric Trials: 0-17 Years
Adult Trials: 18+ Years
18-70 years
Inclusion criteria
The factors, or reasons, that allow a person to participate in a clinical study.
Show details

1. Males and/or Females of non-childbearing potential between 18 and 70 years of age

2. History of mild to moderate hypertension

Exclusion criteria
The factors, or reasons, that prevent a person from participating in a clinical study.
Show details

1. Type 1 or 2 diabetes on prescribed medications

2. Secondary, severe, or malignant hypertension

3. History of a significant cardiovascular event within the last 12 months of enrollment

NCT00422461
Pfizer
Completed
A Dose Finding Study Of PF-00489791 In Patients With Mild To Moderate High Blood Pressure

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[email protected]

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A Dose Finding Study Of PF-00489791 In Patients With Mild To Moderate High Blood Pressure
A Phase 2, Randomized, Placebo-Controlled, Dose-Ranging Study Of PF-00489791 In Subjects With Stage 1 And 2 Essential Hypertension Using Ambulatory Blood Pressure Monitoring (ABPM)
The purpose of this study is to evaluate the safety and blood pressure lowering effect of different doses of PF-00489791 in patients with mild to moderate high blood pressure
Not Provided
Interventional
Phase 2
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Care Provider, Investigator)
Primary Purpose: Treatment
Hypertension
  • Drug: PF-00489791
    PF-00489791 4 mg, oral, tablets, once daily, for 28 days
  • Drug: PF-00489791
    PF-00489791 10 mg, oral, tablets, once daily, for 28 days
  • Drug: PF-00489791
    PF-00489791 20 mg titrated to 40 mg, oral, tablets, once daily, for 28 days
  • Drug: placebo
    placebo, oral, tablets, once daily, for 28 days
  • Experimental: PF-00489791 4 mg
    Intervention: Drug: PF-00489791
  • Experimental: PF-00489791 10 mg
    Intervention: Drug: PF-00489791
  • Experimental: PF-00489791 20 mg titrated to 40 mg
    Intervention: Drug: PF-00489791
  • Placebo Comparator: Placebo
    Intervention: Drug: placebo
Not Provided


*   Includes publications given by the data provider as well as publications
identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
140
January 2008
January 2008   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  1. Males and/or Females of non-childbearing potential between 18 and 70 years of age
  2. History of mild to moderate hypertension

Exclusion Criteria:

  1. Type 1 or 2 diabetes on prescribed medications
  2. Secondary, severe, or malignant hypertension
  3. History of a significant cardiovascular event within the last 12 months of enrollment
Sexes Eligible for Study: All
18 Years to 70 Years   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT00422461
A7331007
No
Not Provided
Not Provided
Director, Clinical Trial Disclosure Group, Pfizer
Pfizer
Not Provided
Study Director: Pfizer CT.gov Call Center Pfizer
Pfizer
October 2009

ICMJE     Data element required by the

International Committee of Medical Journal Editors and the
World Health Organization ICTRP

FOR MORE INFORMATION

Contact a representative by phone, email, or visiting thte study website. To get updates and notications about this trail, sign up using the form below.

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1-800-718-1021

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[email protected]



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