- Men or women of nonchildbearing potential with rheumatoid arthritis (RA), aged 18 to
75 years
- RA disease onset after 16 years of age and has had the disease for at least 6 months
- Must be receiving a stable, well-tolerated oral dose of methotrexate (5 to 25 mg)
taken once weekly for at least 3 months
- Evidence of unstable clinically significant disease