- Healthy men or women of nonchildbearing potential aged 18 to 50 years,
- Body mass index in the range of 18 to 30 kg/m2 and body weight ≥50 kg.
- Family history of sudden death and/or QT prolongation.
- An automatic ECG corrected QT (QTc) interval reading at screening >450 ms and >470 ms
for male and female subjects, respectively.
- Sinus bradycardia at screening, defined as a resting heart rate ?45 bpm. Resting
supine blood pressure at screening