- COPD Patients:
- Subjects with a Body Mass Index (BMI) between 18-32 kg/m2.
- Patients with a diagnosis, for at least 6 months, of moderate to severe (Stage II -
III) COPD as defined by the NIH/WHO Global Initiative for Chronic Obstructive Lung
Disease (GOLD, 2005 revision), whose disease has been stable for 3 months, and have
not had a respiratory tract infection for 6 weeks prior to screening.
- Ability to be maintained off inhaled corticosteroids and other anti-inflammatory
medications (e.g., theophylline) as required by the protocol
- Healthy Volunteers:
- Healthy volunteers should be age (+/- 5 years) and gender matched to the COPD
- No history of asthma, COPD or other lung disease (including, sarcoidosis,
pneumoconiosis, tuberculosis, lung surgery or resection, lung cancer, bronchitis).
- Free from clinically significant disease.
- Exacerbation or hospitalisation for COPD within 3 months of screening, or more than
twice during the preceding year.
- Use of oral corticosteroids in the 6 weeks prior to screen. (Patients who have been
taking inhaled corticosteroids as maintenance COPD therapy are eligible provided the
dose has remained stable for the previous 6 weeks and it is considered that they
could tolerate withdrawal of inhaled corticosteroid for the duration of the study).
- A clearly documented history of adult asthma or other chronic respiratory disorders
apart from COPD (e.g. clinically significant bronchiectasis, pulmonary fibrosis,
- Previous history of bronchial carcinoma, or previous history of lung surgery
(including lung resection, pleurodesis, open lung biopsy, video-assisted lung biopsy)
or invasive lung procedure (e.g., bronchoscopy (with or without biopsy),
- Patients with a history of prior radiation exposure within the past year such that
participation this study would put them over 5 rem for annual radiation exposure for
- History or evidence, based upon a complete medical history, full physical
examination, chest X-ray or clinical laboratory test results, of any other
significant concomitant clinical disease that, in the opinion of the investigator,
could interfere with the subject's safety or the conduct of this study.