Study Examining The Effect Of Renal Impairment On Safety, Toleration And How The Body Processes An Experimental Drug

• Drug: CP-945,598
  
  Administration of CP-945,598 in subjects with normal renal function.
• Drug: CP-945,598
  
  Administration of CP-945,598 in subjects with severe renal impairment.

• Experimental: Normal renal function
  
  Intervention: Drug: CP-945,598
• Experimental: Severe renal impairment
  
  Intervention: Drug: CP-945,598

Inclusion Criteria:

• Normal Subjects: 1.Healthy. 2.Matched for age (± 5 yrs), weight (± 10 kg), and gender ratio (± 2 subjects per gender).
• Subjects with Renal Disease: 1. Severe impairment (Creatinine clearance <30 mL/min) 2. Stable renal disease:no change in the last 30 days. 3. Stable dose of medication and/or treatment. 4. Reasonably well-controlled type 1 and type 2 diabetics

Exclusion Criteria:

• All subjects: Non-prescribed use of drugs of abuse/ recreational drugs; recent treatment with experimental drugs or herbal experiments; EKG and blood pressure parameters falling outside of protocol-specified limits; history of regular alcohol or tobacco use exceeding protocol-specified limits
• Normal subjects: Medically important health conditions; recent use of prescription or non-prescription medications.
• Subjects with renal disease: Subjects requiring dialysis; certain chronic medical conditions; patients who have received renal transplant; severe and/or poorly controlled diabetes; Treatment with protocol-specified drugs that may alter the way the body absorbs or processes CP-945,598.