- Men aged 20 to 45 years, inclusive, at screening.
- Elderly men or women aged 65 years and above as of screening.
- Body mass index (BMI) in the range of 17.6 to 26.4 kg/m2 and body weight ≥45 kg.
Exclusion critereia
- Any significant cardiovascular, hepatic, renal, respiratory, gastrointestinal,
endocrine, immunologic, dermatologic, hematologic, neurologic, or psychiatric disease.
- Any clinically important deviation from normal limits in physical examination, vital
signs, 12-lead ECGs, or clinical laboratory test results. Alanine aminotransferase
(ALT) and aspartate aminotransferase (AST) levels should be below the upper limit of
normal at screening.
- Tobacco use or consumption of any caffeine-containing products (e.g., coffee, tea,
chocolate, or carbonated beverages) or alcoholic beverages within 48 hours before
study day 1 until the end of the inpatient confinement period.
- Men aged 20 to 45 years, inclusive, at screening.
- Elderly men or women aged 65 years and above as of screening.
- Body mass index (BMI) in the range of 17.6 to 26.4 kg/m2 and body weight ≥45 kg.
Exclusion critereia
- Any significant cardiovascular, hepatic, renal, respiratory, gastrointestinal,
endocrine, immunologic, dermatologic, hematologic, neurologic, or psychiatric disease.
- Any clinically important deviation from normal limits in physical examination, vital
signs, 12-lead ECGs, or clinical laboratory test results. Alanine aminotransferase
(ALT) and aspartate aminotransferase (AST) levels should be below the upper limit of
normal at screening.
- Tobacco use or consumption of any caffeine-containing products (e.g., coffee, tea,
chocolate, or carbonated beverages) or alcoholic beverages within 48 hours before
study day 1 until the end of the inpatient confinement period.