- Adults meeting Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition
(DSM-IV) criteria for Bipolar I disorder, most recent episode depressed, with or
without rapid cycling and without psychotic features. Subjects receive therapeutic
dose of lithium, valproate or lamotrigine for at least 4 weeks prior to randomization.
- Patients with ultra-fast rapid cycling (8 or more mood episodes per year)
- Significant heart disease including abnormalities in the heart's rhythm (QT
- Psychotic symptoms (hallucinations and/or delusions).