- At least 18 years of age
- End-stage renal disease in patients receiving a primary or secondary renal allograft
from a cadaveric, living-unrelated, or living-related mismatched donor
- Patients with secondary kidney transplant must have maintained primary graft for at
least 6 months
- Antibody induction within one week of current transplantation
- Multiorgan transplants
- Patients at high-risk of rejection