Study Evaluating FXR-450 in Healthy Japanese Men

• Drug: FXR-450
  
  capsule, single oral doses from 10 mg to 450 mg
• Drug: Placebo
  
  capsule similar to active drug

• Active Comparator: 1
  
  Drug: FXR-450
  Intervention: Drug: FXR-450
• Placebo Comparator: 2
  
  Placebo
  Intervention: Drug: Placebo

Inclusion Criteria:

• Men aged 20 to 45 years.
• Healthy as determined by the investigator.
• Nonsmoker or smoker of fewer than 10 cigarettes per day.

Exclusion Criteria:

• A history or active presence of clinically important medical disease.
• Any surgical or medical condition that may interfere with the absorption, distribution, metabolism, or excretion of the test article (e.g., resection of liver, kidney, gallbladder, or gastrointestinal tract).