Efficacy And Safety Of Parecoxib 40mg vs. Ketoprofen 100mg In The Management Of Acute Renal Colic

• Drug: Ketoprofen 100mg
  
  Ketoprofen 100 mg diluted in 100 ml of normal sodium chloride solution into the established patient's IV line by slow injection in a 20-minute period; and IV dose of 2 ml of normal sodium chloride solution as placebo for Parecoxib by bolus injection
• Drug: Parecoxib 40mg
  
  Parecoxib 40 mg diluted in 2 ml of normal sodium chloride solution administered by bolus injection; and an IV dose of 100 ml of normal sodium chloride solution as placebo for ketoprofen administered in a in a 20-minute period

• Active Comparator: I
  
  Ketoprofen plus placebo parecoxib
  Intervention: Drug: Ketoprofen 100mg
• Active Comparator: II
  
  Parecoxib plus placebo ketoprofen
  Intervention: Drug: Parecoxib 40mg

Inclusion Criteria:

• Patient male or female with a confirmed diagnosis of acute renal colic with moderate to severe pain according to the VAS and Categoric pain scales

Exclusion Criteria:

• The patient has significant renal or hepatic conditions other than uncomplicated kidney stones.
• The patient has a history of clinically significant hypersensitivity to any NSAIDs, cyclooxygenase inhibitors, analgesics or sulfa medications which has a cross sensitivity to the medications used in this study.