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A First In Patient, Study Of Investigational Drug PF-03446962 In Patients With Advanced Solid Tumors

Last updated on February 23, 2019

FOR MORE INFORMATION
Study Location
Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111 United States
Contact
1-800-718-1021
Eligibility criteria
Condition
The disease, disorder, syndrome, illness, or injury that is being studied.
Advanced Solid Tumors
Sex
Females and Males
Age
Pediatric Trials: 0-17 Years
Adult Trials: 18+ Years
18 + years
Inclusion criteria
The factors, or reasons, that allow a person to participate in a clinical study.
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- Advanced measurable or non-measurable solid tumors

- Adequate bone marrow function

- Adequate liver function

- Adequate renal function

- Be able and willing to comply with the study scheduled visits, treatment plans,
laboratory tests and other procedures

Exclusion criteria
The factors, or reasons, that prevent a person from participating in a clinical study.
Show details

- Chemotherapy, radiotherapy, or any investigational cancer therapy within 4 weeks of
first dose of study medication

- Active bleeding disorder, including gastrointestinal bleeding, as evidenced by
hematemesis, hemoptysis or melena in the past 6 months

- Any of the following within the 12 months prior to starting study treatment:
myocardial infarction, severe/unstable angina, coronary/peripheral artery bypass
graft, congestive heart failure, cerebrovascular accident including transient ischemic
attack, or pulmonary embolus; or any other active thromboembolic event

- QTc prolongation defined as QTc >450 msec

- Patients with known brain metastasis

- Patients with peritoneal carcinosis at risk of bleeding

- Major surgical procedure within 4 weeks of treatment

- Pregnancy or breastfeeding

NCT00557856
Pfizer
Completed
A First In Patient, Study Of Investigational Drug PF-03446962 In Patients With Advanced Solid Tumors

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Questions about a trial? Call or email to reach a Pfizer Clinical Trial Contact Center

Pfizer Clinical Trials Contact Center

1-800-718-1021

[email protected]

call now

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Contact a representative by phone, email, or visiting the study website. Please see the references below:

BY PHONE

Pfizer Clinical Trials Contact Center

1-800-718-1021

BY EMAIL

Contact

[email protected]

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