Eligibility criteria
Condition
Colorectal Neoplasms, Neoplasms
Sex
Females and Males
Age
18 + years
Inclusion criteria
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- Advanced solid tumor malignancy (during expansion at the maximum tolerated dose, entry
will be limited to patients wtih adenocarcinoma of the colon or rectum)
- Eastern Cooperative Oncology Group (ECOG) 0 or 1
Exclusion criteria
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- Prior treatment with more than 6 cycles of traditional alkylating agent-based
chemotherapy regimens
- Prior treatment with more than 2 cycles of carboplating-based chemotherapy regimens
- For colorectal cancer patients in the expanded cohorts, prior treatment with more than
2 systemic chemotherapy regimens in the metastatic setting