Effect of Celecoxib Versus Placebo Before and After Knee Surgery on Overall Use of Analgesics After Surgery

• Other: Placebo
  
  Matched oral capsule administered 1 hour prior to surgery and matched oral capsule administered post surgery as needed
• Drug: Celecoxib
  
  400 mg oral capsule as single dose administered 1 hour prior to surgery and 200 mg oral capsule as single dose administered post surgery as needed

• Placebo Comparator: B
  
  Intervention: Other: Placebo
• Experimental: A
  
  Intervention: Drug: Celecoxib

Inclusion Criteria:

Inclusion criteria:

• Diagnosed (or suspected to have) meniscus trauma of the knee requiring ambulatory arthroscopic knee surgery
• Willing to participate in study for 36 hours and come to follow-up visit 7 days post surgery

Exclusion Criteria:

Exclusion criteria:

• Osteoarthritis, inflammatory arthritis, or previous fracture of index joint
• Received acetaminophen or low dose narcotic (vicodin/tylox) within 8 hours of surgery
• Have received oral (4 weeks), intramuscular (2 months), intra-articular (3 months) or soft-tissue (2 months) injections of corticosteroids of the first dose of study medication or intra-artcular injections of hyaluronic acid in the index joint within 9 months of the first dose of study medication